Purpose Thoracolumbar vertebral compression fractures (VCFs) are a leading cause of kyphosis and related biomechanical complications, often resulting in chronic back pain and reduced function. Balloon kyphoplasty has been widely used as a minimally invasive intervention to provide pain relief and restore vertebral height. The SpineJack system is a relatively novel technique that introduces mechanical distraction, offering potentially enhanced vertebral restoration. This study aims to compare these two effective treatments for thoracolumbar fractures.
Materials and Methods This study analyzed 30 patients with thoracolumbar VCFs surgically treated, using the Spine-Jack system (n=10) or balloon kyphoplasty (n=20). Back pain was evaluated as VAS pain score and functional disability was assessed with Oswestry Disability Index (ODI) preoperatively and immediately postoperatively.
Radiological outcomes were measured on plain lateral X-rays, including vertebral height restoration, segmental kyphosis angle, and sagittal vertical axis (SVA). Complications, such as cement leakage and adjacent vertebrae fractures, were recorded. Continuous variables – with t-tests and categorical variables- with chi-square tests, were analyzed. P-value less than 0.05 was considered statistically significant.
Results Both the Spine-Jack system and balloon kyphoplasty were effective in reducing back pain and improving patients’ function, with significant improvements in VAS and ODI scores. However, the Spine-Jack system demonstrated superior vertebral height restoration (85% vs. 72%, p=0.03) and segmental kyphosis angle correction (12° vs. 9°, p=0.032) when compared to balloon kyphoplasty. Complication rates were all low and comparable between the two groups.
Conclusions Although the Spine-Jack system and balloon kyphoplasty are all effective for thoracolumbar VCFs, the Spine-Jack system offered superior radiological outcomes in selected cases. Further studies may explore their complementary roles in managing thoracolumbar VCFs.
Purpose The impact of skeletal muscle mass and bone mineral density (BMD) on frailty after osteoporotic vertebral fractures (OVFs) remains unclear. This study aimed to assess the interplay between frailty, skeletal muscle mass, and bone mineral density in OVFs.
Materials and Methods A total of 66 patients with osteoporotic vertebral compression fractures were enrolled. We collected clinical and radiological data, including age, body mass index (BMI), frailty index, and parameters such as lumbar lordosis, thoracic kyphosis, skeletal muscle mass, and BMD. We then analyzed the relationships between frailty and these variables.
Results The mean age, BMI, BMD T-score, skeletal muscle mass, and frailty index were 78.0±7.8 years, 22.3±3.3 kg/ m², -3.59±0.96, 37.84±6.24 kg, and 2.59±1.08, respectively. Of the 66 patients, 14 (21.1%) were frail prior to fracture, while 37 (56.1%) were frail after fracture, indicating a worsening frailty status. Specifically, 23 patients (34.8%) transitioned from pre-frail to frail following their fracture and had both lower BMD (T-score: -3.7±0.93) and lower skeletal muscle mass (35.74±3.83 kg). Frailty was negatively correlated with BMD (r=-0.28, p=0.02), while BMD was positively correlated with skeletal muscle mass (r=0.29, p=0.02). OVFs were positively correlated with frailty (r=0.33, p=0.01), especially in terms of fatigue (r=0.31, p=0.01) and ambulation (r=0.21, p=0.01).
Conclusions In patients with osteoporotic vertebral fractures, decreased muscle mass and low BMD appear to exacerbate frailty. Furthermore, frailty may be both a contributing and a resulting factor in the development of osteoporotic vertebral fractures.
Purpose This study aimed to compare the clinical effectiveness and potential benefits of ultrasound (US)-guided versus fluoroscopy (FL)-guided cervical retrolaminar block (RLB) in patients with cervical facet joint pain.
Materials and Methods A total of 27 patients aged 40 years or older who were diagnosed with cervical facet joint syndrome based on physical examination and imaging modalities were included. 12 patients of group I treated with US-guided RLB and 15 patients of group II treated with FL-guided RLB. The position of the needle and the distribution of contrast agent were confirmed using fluoroscopic images, and the changes in numeric rating scale (NRS) and neck disability index (NDI) before and 2 weeks after the procedure were compared in the two groups.
Results Radiologically, the target agreement of needle placement in group I was 75%. There was no difference in contrast medium spread between the two groups. Clinically, the mean NRS improved from 7.08±0.52 to 3.08±0.90 in group I (p=0.01) and from 7.20±0.56 to 3.33±0.72 in group II (p=0.01). The mean NDI decreased from 41.67±2.27 before the procedure to 20.83±2.33 after the procedure in group I (p=0.01), and from 40.87±2.61 before the procedure to 21.67±2.02 after the procedure in group II (p=0.01), with no difference between the two groups.
Conclusions US-guided cervical RLB is an effective, radiation-free alternative to FL-guided RLB for managing cervical facet joint pain, offering comparable pain relief and functional improvement.
Advanced imaging technologies have revolutionized the diagnosis and management of spinal pathologies by providing superior precision and efficiency. Modalities such as PET-CT, SPECT, diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS) offer unique insights into the metabolic, structural, and functional aspects of spinal diseases, enabling better differentiation of lesions, improved surgical planning, and early detection of pathological changes. Furthermore, the integration of artificial intelligence (AI) has enhanced imaging workflows by enabling automated analysis, prediction of clinical outcomes, and segmentation of spinal structures. Despite these advancements, challenges such as technical limitations, high costs, and ethical concerns, including issues of data privacy and AI-generated inaccuracies, hinder widespread adoption. This review explores the clinical applications, limitations, and future directions of these emerging technologies, highlighting the need for multidisciplinary collaboration and large-scale research to standardize protocols and optimize patient outcomes. The seamless integration of advanced imaging and AI represents a transformative potential for improving diagnostic accuracy and treatment efficacy in spinal care.
Objective To investigate the utility of a deep learning model in diagnosing traumatic lumbar fractures on computed tomography (CT) images.
Summary of Background Data: CT scans are widely used as the first choice for detecting spinal fractures in patients with severe trauma. Although CT scans have high diagnostic accuracy, fractures can occasionally be missed.
Recently, deep learning has been applied in various fields of medical imaging.
Methods CT images from 480 patients (3695 vertebrae) who visited a level-one trauma center with lumbar fractures were retrospectively analyzed. The diagnostic results were confirmed by two experienced musculoskeletal radiologists and one experienced spine surgeon using magnetic resonance imaging (MRI). Deep learning networks were employed for diagnosis, with 425 cases used for training and 55 cases for testing. Sensitivity, specificity, accuracy, and the area under the receiver operating characteristic curve (AUROC) were calculated to evaluate diagnostic performance.
Results The model successfully identified 107 out of 129 vertebrae with fractures, achieving a sensitivity of 82.95%, a specificity of 93.24%, an AUROC of 0.936, and an overall accuracy of 88.45%.
Conclusions This study demonstrated that the deep learning model showed high accuracy in diagnosing traumatic lumbar fractures. This approach has the potential to assist spine specialists, radiologists, and trauma care experts.
Further validation is needed to determine its effectiveness in clinical settings.
Purpose This study was conducted to identify risk factors predicting the loss of cervical lordosis (LCL) in patients with multilevel ossification of the posterior longitudinal ligament (OPLL) following laminoplasty.
Material and Methods: We conducted a retrospective analysis of data from patients who underwent laminoplasty at Chonnam National University Hospital between January 2013 and December 2022. Various radiological parameters and clinical outcome measures were collected perioperatively. Patients were divided into 2 groups according to the severity of LCL. We examined preoperative radiological parameters associated with LCL.
Results We analyzed data from 109 patients (92 men and 17 women; mean age, 60.31±10.80 years). A higher T1 slope (odds ratio [OR], 1.420; p<0.001) and a lower extension ratio (OR, 0.883; p=0.019) were associated with a higher risk of LCL. T1 slope was shown to be an excellent predictor of LCL, with a cut-off value of 28° (p<0.001, area under the curve=0.918). Also, The T1 slope and extension ratio were statistically significant correlated with clinical outcomes.
Conclusions T1 slope and extension ratio were significantly associated with LCL in patients with multilevel OPLL following laminoplasty. The cut-off value for the T1 slope was 28°, and the cut-off value for the extension ratio was 33. Therefore, in multilevel OPLL patients with a T1 slope exceeding 28° or an extension ratio below 33, a warning regarding the potential LCL should be given before performing cervical laminoplasty.
Objective Postoperative urinary retention (POUR) is a common complication following lumbar spine surgery, significantly affecting functional recovery and Enhanced Recovery After Surgery (ERAS) protocols. POUR can lead to bladder overdistension, infections, prolonged hospital stays, and long-term detrusor dysfunction. Postoperative delirium (POD) can impair cognitive function and mobility, potentially triggering or exacerbating POUR. This study aims to investigate whether POD serves as an independent risk factor for POUR and to analyze other contributing factors to provide clinical management strategies.
Materials and Methods A retrospective cohort study was conducted involving 420 patients who underwent lumbar spine surgery at a single tertiary medical institution between March 2021 and February 2024. POUR was defined as a post-void residual (PVR) bladder volume ≥300 mL measured via bladder ultrasound or requiring catheter reinsertion due to urinary retention. POD was diagnosed within 72 hours postoperatively using the Confusion Assessment Method (CAM) and was classified into three subtypes: hyperactive, hypoactive, and mixed. Multivariate logistic regression analysis was employed to identify the relationship between POD and POUR, with sensitivity and specificity assessed through Receiver Operating Characteristic (ROC) curve analysis.
Results Among 420 lumbar spine surgery patients, 44 (10.5%) experienced POD. Of these, 16 (36.4%) were classified as hyperactive, 20 (45.5%) as hypoactive, and 8 (18.2%) as mixed type. POUR occurred in 28 of the POD patients (63.6%) compared to 71 of 376 patients without POD (18.9%), demonstrating a statistically significant difference (p<0.001). The analysis of POUR incidence by POD subtype revealed rates of 62.5% (10/16) for hyperactive POD, 60.0% (12/20) for hypoactive POD, and 75.0% (6/8) for mixed POD. Patients with mixed POD showed the highest POUR incidence, with a significant difference compared to hyperactive and hypoactive POD (p<0.05). Multivariate logistic regression analysis identified POD as an independent risk factor for POUR, increasing the likelihood by approximately 3.7 times (Odds Ratio, OR: 3.71; 95% Confidence Interval, CI: 1.95–7.06; p<0.001). Among POD subtypes, mixed POD presented the strongest association with POUR, increasing the risk by 4.8 times (OR: 4.84; 95% CI: 2.10–11.15; p<0.001). Hyperactive and hypoactive POD were also significant risk factors, increasing POUR risk by 3.0 times (OR: 3.04; 95% CI: 1.45–6.35; p=0.003) and 3.5 times (OR: 3.48; 95% CI: 1.69–7.19; p=0.001), respectively.
Conclusions This study confirms that postoperative delirium (POD) is an independent risk factor for postoperative urinary retention (POUR) in lumbar spine surgery. The occurrence and subtype of POD significantly influence POUR incidence, with mixed POD presenting the highest risk. These findings highlight the importance of early diagnosis and prevention of POD as a strategy to effectively reduce POUR. A multidisciplinary approach integrating POD and POUR management could optimize postoperative outcomes and improve patient recovery.
Object: This pilot study aimed to evaluate the effectiveness of cervical epidural block (CEB) in improving upper extremity muscle strength in individuals diagnosed with cervical disc herniation.
Materials and Methods 5 patients diagnosed with cervical disc herniation were included and underwent a single CEB treatment. Patients were monitored weekly for 2 weeks via an outpatient clinic. Hand grip strength of affected side and difference of hand grip strength between affected and unaffected side (DHGS) was recorded using dynamometers; before treatment, immediate after treatment, after 1week and 2weeks of treatment. Pain on neck and radiating pain to upper extremity (UE) were measured using the visual analogue scale (VAS) before treatment and 2weeks after treatment.
Results The median age of the patients was 48 (37.0-78.0) years, and the affected disc levels were C5-6 (3 patients), C6-7 (1 patient), and C5-6-7 (1 patient) respectively. In terms of pain, VAS of neck decreased from 6.8 to 3.2, and VAS of UE decreased from 7.4 to 3.0. Both hand grip strength of affected side and DHGS showed improvement when comparing before and after treatment (immediate, 1 week and 2 weeks after treatment) (p<0.001). However, there was no difference between immediate, 1 week and 2 weeks after treatment. The result was same for adjusting age and sex as covariates (p<0.001).
Conclusions These findings suggest that CEB has the potential in improving pain and UE muscle weakness associated with cervical disc herniation. Further large-scale studies are necessary to validate these preliminary outcomes and establish the long-term effectiveness and sustainability of CEB in managing cervical disc herniation.
Objective To investigate stiffness-related disability (SRD) following surgical treatment in adolescent idiopathic scoliosis (AIS) patients particularly with respect to the lowest instrumented vertebra (LIV).
Summary of Background Extensive spinal fusion inevitably results in loss of mobility which may induce SRD during activities of daily living. Few studies have examined SRD after surgical correction for AIS.
Methods Patients who underwent surgical correction for AIS between 2014 and 2021 and were followed up for two years were included. The degree of SRD was evaluated using the Stiffness-Related Disability Index (SRDI) which consists of four categories, each containing three questions, giving a total of 12 components of the questionnaire.
The SRDI scores were compared according to the (LIV) levels. Correlation analysis was performed to examine the relationship between the SRDI and legacy health-related quality of life (HRQOL) measurements.
Results This study included 174 patients (47 males, 127 females) with a mean age of 13.8 years. Among the 12 items of the SRDI, the scores of nine items showed a significant increase after surgery. The total sum of the SRDI scores also significantly increased after surgery. Pearson correlation analysis showed that the SRDI scores were significantly correlated with ODI (Oswestry disability index), nearly all domains, and the total sum of SRS-22 (Scoliosis Research Society-22 questionnaire), and SF-36 (Short Form 36 health questionnaire). No differences in the SRDI score were found among cases with the LIV between T12 and L3. However, The SRDI scores of patients with LIV at L4 were significantly higher than those of patients with other LIV levels. .
Conclusions Various degree of SRD occurred after spinal fusion for AIS. The SRDI significantly correlated with the HRQOL measures. The SRDI score was highest in patients with the LIV at L4 compared to those with other LIV levels.
Purpose Few studies have assessed the prevalence of cervical and thoracic and lumbar (thoracolumbar) intervertebral disc disorders, respectively, using data from the Korean National Health Insurance Service (KNHIS).
The aim is to show the changing prevalence of cervical and thoracolumbar intervertebral disc disorder over the last decade.
Methods Data spanning 2012 to 2021 were collected from the KNHIS, encompassing primary diagnoses related to cervical and thoracolumbar intervertebral disc disorder (ICD 10 code: M50.x and M51.x except M51.4). The agestandardized prevalence was computed using the estimated Korean population in 2020 as a reference. Additionally, age-standardized number of general spinal operations per year was illustrated using the Statistical Yearbook of Major Surgeries in 2021.
Results In 2012, the age-standardized prevalence of cervical intervertebral disc disorder was 11,383 persons per 100,000 decreasing to 8,860 persons per 100,000 persons in 2021. This decline was observed in both male (from 10,101 to 8,012) and female (from 12,690 to 9,709). For thoracolumbar intervertebral disc disorders, the agestandardized prevalence decreased from 27,506 to 18,903 persons per 100,000 persons from 2012 to 2021. Notably, the age-standardized prevalence showed a greater increase in individuals aged 60 or older compared to those aged 50, for both sexes. However, there was an increase in the number of general spinal operation from 2012 to 2021.
Conclusions While the overall age-standardized prevalence of cervical and thoracolumbar intervertebral disc disorders decreased between 2012 and 2021 across all age groups, the number of general spinal operations increased during the same period.
Spinal cord injury (SCI) distinguishes itself from peripheral nerve injury by causing devastating and irreversible damage to the spine, resulting in profound motor, sensory, and autonomic dysfunction. The ensuing complex microenvironment of SCI, characterized by hemorrhage, inflammation, and scar formation, poses substantial challenges to regeneration and complicates numerous transplantation strategies. Recent research has shifted its focus towards manipulating the intricate SCI microenvironment to enhance regeneration, with some approaches demonstrating significant therapeutic efficacy. Consequently, the reconstruction of an appropriate microenvironment post-transplantation emerges as a potential therapeutic solution for SCI. This review aims to provide a comprehensive overview, firstly summarizing the influential compositions of the microenvironment and their diverse effects on regeneration. Secondly, we highlight recent research employing various transplantation strategies to modulate distinct microenvironments induced by SCI, aiming to facilitate regeneration. Lastly, we discuss prospective transplantation strategies for SCI, emphasizing the importance of addressing the complex microenvironment for successful therapeutic outcomes.
The standard method for treating posterior pelvic ring injuries involves sacroiliac joint cannulated lag screw fixation, necessitating repeated fluoroscopy and leading to radiation exposure. The O-arm navigation system, designed for spine screw fixation, is applied in pelvic injuries to enhance precision. A successful case involved a 39-year-old male with a complex pelvic injury, where sacroiliac screw fixation was performed in the prone position using the O-arm guide. The patient, injured at a construction site, showed fractures and widening of the symphysis pubis and right sacroiliac joint. Surgery was planned for both lumbar and pelvic regions due to an L3 burst fracture. The O-arm system demonstrated efficacy in precise screw placement, reducing surgical duration, and minimizing complications. The discussion emphasizes early pelvic fixation benefits, with percutaneous iliosacral screws standing out. Conventional fluoroscopy-guided methods pose challenges, and the O-arm system proves advantageous, especially for less experienced surgeons. Future advancements may enable pelvic surgery using the O-arm without C-arm guidance if instrumentation for pelvis fixation is developed.
Background This study aims to assess the clinical and radiographic outcomes of biportal endoscopic lumbar discectomy compared to microscopic lumbar discectomy in obese patients with lumbar herniated discs. Previous research has established a positive correlation between operation time and estimated blood loss in obese patients undergoing microscopic lumbar discectomy, based on an increase in body mass index. However, no studies have specifically examined the outcomes of biportal endoscopic lumbar discectomy in this patient population. Therefore, this study seeks to fill this research gap and provide valuable insights into the effectiveness of these two surgical approaches for obese patients with lumbar herniated discs.
Methods This retrospective multicenter study analyzed and compared clinical and radiological data from 48 obese patients with a body mass index (BMI) greater than 30 kg/m2 who underwent either microscopic or biportal endoscopic lumbar discectomy. The study assessed clinical outcomes using the visual analog scale (VAS), Oswestry Disability Index (ODI), and EuroQol-5D (EQ-5D) scores. Radiological data were obtained through magnetic resonance imaging (MRI) scans.
Results The study included a total of 48 patients, with 31 patients undergoing microscopic discectomy and 17 patients undergoing biportal endoscopic discectomy. Both groups showed improvements in VAS, ODI, and EQ-5D scores following surgery compared to preoperative scores. However, there was no significant difference in these outcome measures between the two surgical techniques. Although there was a no significant difference in the occurrence of recurrent disc herniation confirmed by postoperative MRI, there was significant difference in the number of patients requiring additional surgery between the two groups.
Conclusions For obese patients with lumbar disc herniation that did not respond to conservative treatment, this study found no significant differences in clinical or radiological outcomes between microscopic and biportal endoscopic surgery methods. However, it is worth noting that the biportal group had a lower incidence of reoperation compared to the microscopic group.
Objective Proximal junctional fracture (PJFx) at the uppermost instrumented vertebra (UIV) or UIV+1 is the most common mechanism of PJF. There are few studies assessing the radiographic progression after PJFx development.
Therefore, this study sought to identify the risk factors for radiographic progression of PJFx in surgical treatment for ASD.
Methods In this retrospective study, among 317 patients aged > 60 years who underwent ≥5-level fusion from the sacrum, 76 with PJFx development were included. According to the change in proximal junctional angle (PJA), two groups were created: Group P (change ≥10°) and Group NP (change <10°). Patient, surgical, and radiographic variables were compared between the groups to demonstrate risk factors for PJFx progression using uni- and multivariate analysis. The receiver operating characteristic (ROC) curve was used to calculate cutoff values. Clinical outcomes, such as visual analog scale (VAS) scores for back and leg pain, the Oswestry Disability Index (ODI) score, and the Scoliosis Research Society (SRS)-22 score, and revision rate were compared between the two groups.
Results The mean age at the index surgery was 71.1 years, and there were 67 women enrolled in the study (88.2%).
There were 45 patients in Group P and 31 in Group NP. A mean increase of PJA was 15.6° (from 23.2° to 38.8°) in Group P and 3.7° (from 17.2° to 20.9°) in Group NP. The clinical outcomes were significantly better in Group NP than Group P, including back VAS score, ODI value, and the SRS-22 scores for all items. Revision rate was significantly greater in group P than in group NP (17.8% vs. 51.6%, p=0.001). Multivariate analysis revealed that overcorrection relative to the age-adjusted ideal pelvic incidence (PI)–lumbar lordosis (LL) target at the index surgery (odds ratio [OR]=4.484, p=0.030], PJA at the time of PJFx identification (OR=1.097, p=0.009), fracture at UIV versus UIV+1 (OR =3.410, p=0.027) were significant risk factors for PJFx progression. The cutoff value of PJA for PJFx progression was calculated as 21° using the ROC curve.
Conclusions The risk factors for further progression of PJFx were overcorrection relative to age-adjusted PI–LL target at the index surgery, PJA > 21° at initial presentation, and fracture at the UIV level. Close monitoring is warranted for such patients not to miss the timely revision surgery.
Purpose The biplanar whole body imaging system (EOS) is a new tool for measuring whole body sagittal alignment in a limited space. This tool may affect the sagittal balance of patients compared to conventional whole spine radiography (WSX). This study is to investigate the difference in sagittal alignment between WSX and EOS.
Materials and Methods We compared spinal and pelvic sagittal parameters in 80 patients who underwent EOS and WSX within one month between July 2018 and September 2019.The patients were divided based on sagittally balanced and imbalanced groups according to pelvic tilt (PT) >20˚, pelvic incidence-lumbar lordosis >10°, C7-sagittal vertical axis (SVA) > 50 mm in WSX.
Results In sagitally imbalanced group, for WSX versus EOS, the pelvic parameters demonstrated compensation in EOS with smaller PT (27.4±11.6° vs. 24.9±10.9°, p=0.003), greater sacral slope (SS), and patients tended to stand more upright with smaller C7-SVA (58.4±17 mm vs. 48.9±57.3 mm, p=0.003), T1-pelvic angle (TPA), T5-T12, and T2-T12.
However, in sagitally balanced group, these differences were less pronounced only with smaller PT (10.8±6.9° vs.
9.4±4.7°, p=0.04), TPA and T2-T12 angle, but SS and C7-SVA were similar (p>0.05).
Conclusions EOS shows a negative SVA shift and lesser pelvic tilt than WSX especially in patients with sagittal imbalance. When making a surgical plan, surgeon should consider these differences between EOS and WSX.
After posterior cervical arthrodesis, many problems can arise, including adjacent segment degeneration and the related adjacent segment disease (ASD). As indicated by studies on the causes of ASD, posterior cervical arthrodesis can produce biomechanical and kinematic changes in adjacent unfused segments due to inappropriate forces.
Several studies have been conducted to determine the appropriate lowest instrumented vertebra, specifically regarding whether to cross the cervicothoracic junction via extension of long-segment posterior cervical fusion. We searched for relevant articles in electronic databases including PubMed, the Cochrane Registry, Embase, and Ovid.
Five meta-analyses were reviewed on this topic. Among these, Goyal et al. (2019), Rajjoub et al. (2022), and Chang et al. (2022) argued that ending instrumentation at the cervical level was associated with higher rates of ASD and reoperation. However, Truumees et al. (2022) and Coban et al. (2022) found no statistically significant differences between cases of instrumentation ending at the cervical and thoracic levels in the rates of ASD and requirement of revision surgery. Cervicothoracic junction breakage is a known possibility after cervical spine surgery because of the anatomical fragility of the junction. Terminating at the thoracic level reduces the stress on the cervicothoracic junction, thereby decreasing complications such as cervicothoracic junction breakage and lowering the frequency of reoperation. Based on the findings published to date, instrumentation across the cervicothoracic junction can be reasonably recommended in cases of multilevel posterior cervical fusion based on the lower reoperation and higher fusion rate.
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